![]() Dyspepsia (gnawing or burning pain in the pit of your stomach, sometimes with bloating).Potential side effects of NSAIDs include: Some side effects will only be apparent from your blood tests, so it is important to get regular complete blood counts (CBCs) every 3-4 months, including tests of your liver and kidney function. Most side effects will go away once the drug is stopped. These side effects can be similar to symptoms of increased lupus, so it is important to notify your doctor if they occur. What side effects can occur from taking NSAIDs? ![]() Your doctor will help you to decide which type of NSAID works best to treat your lupus symptoms, while minimizing the possible side effects. A Cox-2 inhibitor is sometimes called a “selective” inhibitor. However, some newer NSAIDs, such as celecoxib (Celebrex), block only the Cox-2 enzyme, which may help your body to avoid some of the more traditional side effects. Since the Cox-1 enzyme helps some of your organ systems to function normally, you may experience some side effects when taking NSAIDs, such as upset stomach. Most NSAIDs block both Cox-1 and Cox-2 enzymes. ![]() So, by stopping your body from making prostaglandins, NSAIDs allow you to experience less swelling and less pain. Cox-2 controls the formation of the prostaglandins involved in your body’s inflammatory response. Specifically, Cox-1 controls the formation of the prostaglandins involved in the normal function of many of your body’s organs. These prostaglandins are controlled by enzymes-proteins that help to bring about chemical changes in your body-called Cox-1 and Cox-2. Prostaglandins are involved in both your body’s normal “maintenance” and your body’s inflammatory response. NSAIDs work at a chemical level by blocking the formation of molecules in your body called prostaglandins. Everyone responds differently to different medications, so you and your doctor should work together to find the most effective NSAID for your lupus symptoms. There are many NSAIDs currently on the market common examples include ibuprofen (Advil, Motrin), naproxen (Naprosyn, Alleve), etodolac (Lodine), celecoxib (Celebrex), and meloxicam (Mobic). NSAIDs come in both prescription and over-the-counter forms, but you should always talk to your doctor before taking any over-the-counter medication. NSAIDs are milder than many other lupus drugs and may be taken either alone to treat a mild flare or in combination with other medications. NSAID stands for “non-steroidal anti-inflammatory drug.” These anti-inflammatory medications relieve some lupus symptoms by reducing the inflammation responsible for the stiffness and discomfort in your muscle, joints, and other tissues.
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